180 Life Sciences Announces Publication of a Review on the Treatments for Early Stage Dupuytren’s Disease
News provided by180 Life Sciences Corp.
Jan 25, 2023, 8:45 AM ET
PALO ALTO, Calif., Jan. 25, 2023 (GLOBE NEWSWIRE) -- 180 Life Sciences Corp. (NASDAQ: ATNF) (“180 Life Sciences” or the “Company”), today announced the publication of a review entitled ‘Treatments for early stage Dupuytren’s disease: an evidence-based approach’ in The Journal of Hand Surgery (European Volume).
In the publication, Professor Jagdeep Nanchahal, chairman of the medical advisory board of 180 Life Sciences, and his colleague at the University of Oxford, describe the limitations for the current treatments for late-stage Dupuytren’s disease and the lack of evidence based on randomized double blind, placebo-controlled trials for treatments for early-stage disease, such as intranodular injection of steroid or radiotherapy. They go on to describe how tumor necrosis factor (TNF) was identified as a potential therapeutic target through the study of cellular signaling mechanisms in tissue from patients. They also describe the results of the phase 2a dose ranging trial, which identified the most efficacious dose and formulation of adalimumab (an anti-TNF). This was followed by a phase 2b trial, which met the primary endpoint of reduction in nodule hardness and the secondary endpoint of decrease in nodule size, indicating the potential to control progression of early-stage disease.
Professor Marc Feldmann FRS, co-chairman of 180 Life Sciences said, “This review in a pre-eminent journal in the field summarizes the evidence for current treatments for early-stage Dupuytren’s disease based on systematic reviews of the literature and the advances made in the field by Professor Nanchahal and his team at the University of Oxford.”
Dr. James Woody, CEO of 180 Life Sciences, stated, “We look forward to advancing the laboratory and clinical findings that support the potential for anti-TNF to treat the large number of patients with early-stage Dupuytren’s disease.”
About 180 Life Sciences Corp.
180 Life Sciences Corp. is a clinical-stage biotechnology company driving ground-breaking studies into clinical programs which are seeking to address major unmet medical needs. The Company’s focus is a novel program to treat several inflammatory disorders using anti-TNF (tumor necrosis factor).
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180 Life Sciences Corp